Elevated Serum DcR3, Fas, and NLR Ratio are correlated with the progression of Liver Cirrhosis

Zhijun Lin; Yanchao Chen; Jiangying Long; Xianhua Zhang

doi:10.62347/HWYM7712

Elevated Serum DcR3, Fas, and NLR Ratio are correlated with the progression of Liver Cirrhosis

Am J Transl Res. 2025 Feb 15;17(2):1057-1064. doi: 10.62347/HWYM7712. eCollection 2025.

Authors

Zhijun Lin¹, Yanchao Chen², Jiangying Long³, Xianhua Zhang⁴

Affiliations

¹ Department of Nephrology, The Second Affiliated Hospital, Shantou University Medical College Shantou 515041, Guangdong, China.
² Clinical Laboratory, The Second Affiliated Hospital, Shantou University Medical College Shantou 515041, Guangdong, China.
³ Department of Internal Medicine, Guangzhou Eighth People's Hospital, Guangzhou Medical University Guangzhou 510440, Guangdong, China.
⁴ Department of Hepatology and Infectious Diseases, The Second Affiliated Hospital, Shantou University Medical College Shantou 515041, Guangdong, China.

Abstract

Objective: To investigate the correlation between serum levels of decoy receptor 3 (DcR3), neutrophil-to-lymphocyte ratio (NLR), and Fas with the prognosis of liver cirrhosis, with the aim of providing clinical reference for the evaluation of cirrhosis.

Methods: 123 patients with liver cirrhosis were retrospectively selected as the observation group, and 123 healthy individuals as the control group. Serum DcR3, Fas, and peripheral blood NLR were measured and compared between groups. Differences in these indicators were analyzed among patients with varying cirrhosis types and those with liver cancer. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive value of each indicator for cirrhosis progression to liver cancer.

Results: Serum levels of DcR3, Fas, and peripheral blood NLR were significantly higher in the observation group compared to the control group (P < 0.05). Among cirrhosis subtypes, patients with liver cancer exhibited the highest levels of DcR3, Fas, and NLR, followed by those with decompensated cirrhosis, with the lowest levels observed in patients with compensated cirrhosis (P < 0.05). Additionally, cirrhosis patients showed significantly higher levels of these markers than compensated cirrhosis patients (P < 0.05). Among patients with different grades of cirrhosis, the levels of each indicator were highest in grade C, followed by grade B, and lowest in grade A (P < 0.05). ROC curve analysis showed that DcR3, Fas, and NLR were significant predictors of cirrhosis progression to liver cancer (P < 0.05).

Conclusion: Serum levels of DcR3, Fas, and peripheral blood NLR increase with the progression of liver cirrhosis, demonstrating significant diagnostic value for assessing the prognosis of cirrhosis.

Keywords: Fas; Liver cirrhosis; decoy receptor 3; neutrophil-to-lymphocyte ratio.