Effects of aniracetam on delayed matching-to-sample performance of monkeys and pigeons

Pharmacol Biochem Behav. 1985 May;22(5):745-52. doi: 10.1016/0091-3057(85)90523-4.


A 3-choice, variable-delay, matching-to-sample procedure was used to evaluate drugs in both pigeons and monkeys while tested under nearly-identical conditions. Aniracetam (Roche 13-5057) improved accuracy of matching at all retention intervals following oral administration (12.5, 25 and 50 mg/kg) to macaque monkeys, with a maximal effect at 25 mg/kg. Aniracetam also antagonized scopolamine-induced impairment of the monkey's performance. Intramuscular administration of these same doses of aniracetam produced a similar, but not significant trend toward improved matching accuracy in pigeons.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cognition / drug effects*
  • Columbidae
  • Female
  • Macaca fascicularis
  • Male
  • Memory, Short-Term / drug effects*
  • Psychomotor Performance / drug effects*
  • Pyrrolidinones / pharmacology*
  • Scopolamine / antagonists & inhibitors
  • Species Specificity


  • Pyrrolidinones
  • aniracetam
  • Scopolamine