Chylomicronaemia in multiple myeloma

Scand J Haematol. 1985 May;34(5):436-41. doi: 10.1111/j.1600-0609.1985.tb00774.x.


A patient with multiple myeloma presented with an accumulation of chylomicron-like particles. This rare finding resembled that of the type V hyperlipoproteinaemia phenotype. The lipid and lipoprotein concentration and composition were compared with values obtained from other patients with multiple myeloma, patients with the type V hyperlipoproteinaemia phenotype (accumulation of chylomicrons and very low density lipoproteins), and normal subjects. An immunoglobulin-lipid complex was demonstrated in our patient. This complex was found not to be associated with the chylomicrons and was detected only in the lipoprotein-deficient plasma. Lipid and lipoprotein concentration and composition differed from the other groups. Very low density lipoprotein concentration was reduced, and there was thus a marked difference from the type V phenotype. The chylomicrons derived from this patient were also richer in apolipoprotein C compared to chylomicrons derived from the patients with type V hypolipoproteinaemia. It appears that the abnormal composition of the triglyceride-rich lipoproteins observed in this patient renders her refractory to the normal pathways of metabolism.

Publication types

  • Case Reports

MeSH terms

  • Cholesterol / blood
  • Chylomicrons / blood*
  • Female
  • Humans
  • Hyperlipoproteinemia Type V / blood
  • Hyperlipoproteinemia Type V / complications
  • Lipolysis
  • Lipoproteins, HDL / blood
  • Lipoproteins, VLDL / blood
  • Melphalan / therapeutic use
  • Middle Aged
  • Multiple Myeloma / blood*
  • Multiple Myeloma / complications
  • Multiple Myeloma / drug therapy
  • Triglycerides / blood


  • Chylomicrons
  • Lipoproteins, HDL
  • Lipoproteins, VLDL
  • Triglycerides
  • Cholesterol
  • Melphalan