Community-associated New Delhi metallo-beta-lactamase-producing carbapenem-resistant Enterobacterales: multiple states, from September 2021 through September 2022

Sophie Jones; Richard Stanton; Marisa D'Angeli; Audrey Brezak; Jenna Sinkevitch; Megan Sredl; Shermalyn Greene; Kelley Garner; Trenton Gulley; Celina Santiago; Wei Wang; Samuel Cincotta; Maroya Spalding Walters

doi:10.1017/ice.2025.28

Community-associated New Delhi metallo-beta-lactamase-producing carbapenem-resistant Enterobacterales: multiple states, from September 2021 through September 2022

Infect Control Hosp Epidemiol. 2025 May;46(5):544-547. doi: 10.1017/ice.2025.28. Epub 2025 Mar 24.

Authors

Sophie Jones^{1

2}, Richard Stanton², Marisa D'Angeli³, Audrey Brezak³, Jenna Sinkevitch^{4

5}, Megan Sredl⁶, Shermalyn Greene⁶, Kelley Garner⁷, Trenton Gulley⁷, Celina Santiago⁸, Wei Wang², Samuel Cincotta^{2

9}, Maroya Spalding Walters^{2

9}

Affiliations

¹ Epidemic Intelligence Service, CDC, Atlanta, GA, USA.
² Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, CDC, Atlanta, GA, USA.
³ Washington State Department of Health, Tumwater, WA, USA.
⁴ Bureau of Epidemiology, Pennsylvania Department of Health, Harrisburg, PA, USA.
⁵ Council of State and Territorial Epidemiologists, Atlanta, GA, USA.
⁶ North Carolina Department of Health and Human Services, Raleigh, NC, USA.
⁷ Arkansas Department of Health, Little Rock, AR, USA.
⁸ Bureau of Communicable Diseases, New York City Department of Health and Mental Hygiene, Queens, NY, USA.
⁹ US Public Health Service, Rockville, MD, USA.

PMID: 40123437
DOI: 10.1017/ice.2025.28

Abstract

In the United States, New Delhi metallo-beta-lactamase (NDM)-producing carbapenem-resistant Enterobacterales (CRE) are frequently associated with healthcare encounters. From September 2021 to September 2022, 21 patients with NDM-CRE identified from urine and without healthcare exposure were reported to the Centers for Disease Control and Prevention. Isolates were genetically similar to healthcare-associated strains.

MeSH terms

Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents / pharmacology
Carbapenem-Resistant Enterobacteriaceae* / drug effects
Carbapenem-Resistant Enterobacteriaceae* / genetics
Carbapenem-Resistant Enterobacteriaceae* / isolation & purification
Carbapenems / pharmacology
Community-Acquired Infections* / epidemiology
Community-Acquired Infections* / microbiology
Enterobacteriaceae Infections* / drug therapy
Enterobacteriaceae Infections* / epidemiology
Enterobacteriaceae Infections* / microbiology
Female
Humans
Male
Microbial Sensitivity Tests
Middle Aged
United States / epidemiology
Young Adult
beta-Lactamases*

Substances

beta-Lactamases
beta-lactamase NDM-1
Carbapenems
Anti-Bacterial Agents