Association between different triglyceride glucose index-related indicators and overactive bladder

Yuhan Huang; Kaiyuan Wang; Wenjing Wang; Xueqian Sun; Shihao Zhao; Yuanyuan Miao; Yuchun Tao; Lina Jin

doi:10.1016/j.diabres.2025.112128

Association between different triglyceride glucose index-related indicators and overactive bladder

Diabetes Res Clin Pract. 2025 May:223:112128. doi: 10.1016/j.diabres.2025.112128. Epub 2025 Mar 22.

Authors

Yuhan Huang¹, Kaiyuan Wang², Wenjing Wang³, Xueqian Sun⁴, Shihao Zhao⁵, Yuanyuan Miao⁶, Yuchun Tao⁷, Lina Jin⁸

Affiliations

¹ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Jilin, Changchun, China. Electronic address: hyh23@mails.jlu.edu.cn.
² Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Jilin, Changchun, China. Electronic address: wangky23@mails.jlu.edu.cn.
³ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Jilin, Changchun, China. Electronic address: wwj24@mails.jlu.edu.cn.
⁴ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Jilin, Changchun, China. Electronic address: sxq24@mails.jlu.edu.cn.
⁵ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Jilin, Changchun, China. Electronic address: shzhao23@mails.jlu.edu.cn.
⁶ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Jilin, Changchun, China. Electronic address: miaoyy23@mails.jlu.edu.cn.
⁷ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Jilin, Changchun, China. Electronic address: tyc@jlu.edu.cn.
⁸ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Jilin, Changchun, China. Electronic address: jinln@jlu.edu.cn.

PMID: 40127871
DOI: 10.1016/j.diabres.2025.112128

Abstract

Background: Overactive bladder (OAB) is a syndrome marked by urinary urgency. Given the crucial role of metabolic anomalies in the pathogenesis of OAB, the aim of this study was to investigate the associations between different triglyceride glucose index (TyG)-related indicators and OAB.

Methods: 9024 participants aged ≥ 20 years from NHANES 2005-2018 were involved. Weighted multivariate logistic regression was employed to assess the relationship between three TyG-related indicators and OAB with subgroup and interaction analyses. In addition, ROC, DeLong's test and confusion matrix were further utilized to assess the predictive power of different indicators for OAB in the total population versus different subgroups of the population.

Results: TyG-related indicators were positively associated with OAB. The associations were statistically different in age and physical activity subgroups (all p for interaction < 0.1). In the whole population, TyG-WHtR demonstrated the highest predictive ability, with the largest AUC of 0.625 (95 %CI: 0.609, 0.641), and was relatively more predictive in the < 60 years and moderate-to-vigorous physical activity subgroups.

Conclusions: Positive associations of TyG-related indicators with OAB were observed. TyG-WHtR has the strongest predictive performance for OAB in the total population.

Keywords: Insulin resistance; NHANES; Overactive bladder; TyG-related indicators.

MeSH terms

Adult
Aged
Blood Glucose* / analysis
Blood Glucose* / metabolism
Cross-Sectional Studies
Exercise
Female
Humans
Male
Middle Aged
Nutrition Surveys
Triglycerides* / blood
Urinary Bladder, Overactive* / blood
Urinary Bladder, Overactive* / epidemiology
Young Adult

Substances

Triglycerides
Blood Glucose