Editorial: Meta-Analysis of Individual Participant Data From Trials of Selective Serotonin Reuptake Inhibitors for Pediatric Obsessive-Compulsive Disorder: A Gold Standard Approach

Gail A Bernstein

doi:10.1016/j.jaac.2025.03.016

Editorial: Meta-Analysis of Individual Participant Data From Trials of Selective Serotonin Reuptake Inhibitors for Pediatric Obsessive-Compulsive Disorder: A Gold Standard Approach

J Am Acad Child Adolesc Psychiatry. 2025 Jul;64(7):768-769. doi: 10.1016/j.jaac.2025.03.016. Epub 2025 Mar 24.

Author

Gail A Bernstein¹

Affiliation

¹ University of Minnesota Medical School, Masonic Institute for the Developing Brain, Minneapolis, Minnesota. Electronic address: berns001@umn.edu.

PMID: 40139344
DOI: 10.1016/j.jaac.2025.03.016

Abstract

Pediatric obsessive-compulsive disorder (OCD) is a common (2% prevalence) and potentially debilitating condition.¹ Early identification and intervention are critical because they may improve outcomes for children and adolescents with OCD and prevent long-term morbidity. The individual participant data (IPD) meta-analysis by Cohen and colleagues² explores the efficacy of short-term trials of selective serotonin reuptake inhibitors (SSRIs) compared to placebo for treating children and adolescents with OCD. It also investigates the moderating effects of baseline patient variables on treatment outcome.

Publication types

Editorial

MeSH terms

Adolescent
Child
Humans
Meta-Analysis as Topic*
Obsessive-Compulsive Disorder* / drug therapy
Selective Serotonin Reuptake Inhibitors* / therapeutic use
Treatment Outcome

Substances

Selective Serotonin Reuptake Inhibitors