Mouth and genital ulcers with inflamed cartilage: MAGIC syndrome. Five patients with features of relapsing polychondritis and Behçet's disease

Am J Med. 1985 Jul;79(1):65-72. doi: 10.1016/0002-9343(85)90547-9.

Abstract

Five patients with features of coexistent relapsing polychondritis and Behçet's disease are described. Review of the literature supports the overlap of the clinical manifestations of these two conditions. A common immunologic abnormality is likely, and elastin is cited as a possible target antigen. The "mouth and genital ulcers with inflamed cartilage (MAGIC) syndrome" is the proposed name for this entity.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Autoantibodies / immunology
  • Behcet Syndrome / complications*
  • Behcet Syndrome / immunology
  • Child
  • Female
  • Genital Diseases, Female / complications
  • Genital Diseases, Male / complications
  • Humans
  • Male
  • Middle Aged
  • Mouth Diseases / complications
  • Polychondritis, Relapsing / complications*
  • Polychondritis, Relapsing / immunology
  • Skin Ulcer / complications
  • Ulcer / complications

Substances

  • Autoantibodies