Metered dose inhaler induced bronchospasm in asthmatic patients

Ann Allergy. 1985 Jul;55(1):25-7.


Beta-adrenergic agonists in metered dose inhalers (MDIs) are used extensively in the treatment of asthma. Previously we reported that 23 of 1450 (1.6%) of our asthmatic patients experienced immediate bronchoconstriction after using MDI-albuterol. In this study we investigated immediate bronchoconstriction after use of MDI-metaproterenol and after placebo-inhaler with "inert ingredients" only. Results suggest that those patients who complained of chest tightness or lack of relief following the use of MDI beta-adrenergic agonists are having true bronchoconstriction. The bronchoconstrictive response is most likely caused by the propellants or the other inert ingredients contained in these MDIs.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Administration, Intranasal / adverse effects*
  • Aerosol Propellants / adverse effects*
  • Aerosols / adverse effects*
  • Asthma / drug therapy*
  • Asthma / physiopathology
  • Bronchial Spasm / chemically induced*
  • Bronchial Spasm / physiopathology
  • Forced Expiratory Volume
  • Humans
  • Metaproterenol / therapeutic use


  • Aerosol Propellants
  • Aerosols
  • Metaproterenol