Deciphering SARS-CoV-2 evolution under antibody immune pressure

Fanchong Jian; Yunlong Cao

doi:10.1016/j.it.2025.03.002

Deciphering SARS-CoV-2 evolution under antibody immune pressure

Trends Immunol. 2025 Apr;46(4):263-265. doi: 10.1016/j.it.2025.03.002. Epub 2025 Mar 27.

Authors

Fanchong Jian¹, Yunlong Cao²

Affiliations

¹ Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China; Changping Laboratory, Beijing, China.
² Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China; Changping Laboratory, Beijing, China. Electronic address: yunlongcao@pku.edu.cn.

PMID: 40155215
DOI: 10.1016/j.it.2025.03.002

Abstract

The ongoing evolution of SARS-CoV-2 poses significant challenges to existing neutralizing antibodies and vaccines through immune escape mutations. By leveraging genomic surveillance and antibody deep mutational scanning (DMS) data, Raharinirina and colleagues developed a computational framework to elucidate region-specific SARS-CoV-2 variant dynamics and predict evolutionary trends under population immunity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Neutralizing* / immunology
Antibodies, Viral* / immunology
COVID-19* / immunology
COVID-19* / virology
Evolution, Molecular
Humans
Immune Evasion / genetics
Mutation
SARS-CoV-2* / genetics
SARS-CoV-2* / immunology
Spike Glycoprotein, Coronavirus / genetics
Spike Glycoprotein, Coronavirus / immunology

Substances

Antibodies, Viral
Antibodies, Neutralizing
Spike Glycoprotein, Coronavirus