Photoinduced Carbamoylarylation of Alkynes with N-Aryl Oxamic Acids

Org Lett. 2025 Apr 18;27(15):3947-3951. doi: 10.1021/acs.orglett.5c00866. Epub 2025 Apr 2.

Abstract

1,2-Difunctionalization of alkynes is an attractive synthetic protocol, because it can achieve a high step economy and provide various complex organic molecules. This study demonstrates the visible-light-induced carbamoylarylation of terminal alkynes using N-aryl oxamic acids as bifunctional reagents. The transformation involves the addition of carbamoyl radicals to alkenes, resulting in 1,4-aryl migration via C(aryl)-N bond cleavage to afford the corresponding arylacrylamides in moderate to good yields.