Immune repertoire profiling uncovers pervasive T cell clonal expansions in benign prostatic hyperplasia

J Clin Invest. 2025 Apr 3;135(11):e186939. doi: 10.1172/JCI186939. eCollection 2025 Jun 2.

Abstract

We discovered T-cell clonal expansions in benign prostatic hyperplasia, indicative of a specific adaptive immune response and with implications for disease pathogenesis and new treatments.

Keywords: Immunology; Inflammation; Prostate cancer; Reproductive biology; T cells; Urology.

MeSH terms

  • Aged
  • Clone Cells
  • Humans
  • Male
  • Middle Aged
  • Prostatic Hyperplasia* / genetics
  • Prostatic Hyperplasia* / immunology
  • Prostatic Hyperplasia* / pathology
  • T-Lymphocytes* / immunology
  • T-Lymphocytes* / pathology