Tissue-like multicellular development triggered by mechanical compression in archaea

Science. 2025 Apr 4;388(6742):109-115. doi: 10.1126/science.adu0047. Epub 2025 Apr 3.

Abstract

The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal multicellularity in haloarchaea, forming tissue-like structures. These archaeal tissues are mechanically and molecularly distinct from their unicellular lifestyle, mimicking several eukaryotic features. Archaeal tissues undergo a multinucleate stage followed by tubulin-independent cellularization, orchestrated by active membrane tension at a critical cell size. After cellularization, tissue junction elasticity becomes akin to that of animal tissues, giving rise to two cell types-peripheral (Per) and central scutoid (Scu) cells-with distinct actin and protein glycosylation polarity patterns. Our findings highlight the potential convergent evolution of a biophysical mechanism in the emergence of multicellular systems across domains of life.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural

MeSH terms

  • Actins / metabolism
  • Archaeal Proteins / metabolism
  • Biological Evolution
  • Biomechanical Phenomena
  • Elasticity
  • Glycosylation
  • Stress, Mechanical

Substances

  • Actins
  • Archaeal Proteins