Background: Excessive weight gain, aging-related skin laxity, and weakened digastric muscle contribute to the formation of submental fullness.
Objectives: The aim of this study was to investigate the efficacy and safety of combined high-intensity focused electrical stimulation (HIFES) and novel Synchronized Radiofrequency+ (Sync RF+) energies for submental volume reduction, and in addition to examine the effect of HIFES and Sync RF treatment on fat volume in the cheek area.
Methods: Thirty-three subjects (n = 33) received 4 treatments once weekly, on the submental and cheek area. Two- and three-dimensional photographs were taken at baseline, after the fourth treatment, and at both follow-ups at 1 and 3 months posttreatment. MRI scanning was performed at baseline, and at both follow-ups.
Results: The overall submental volume decreased by 25.12% at 1 month and by 36.20% at 3 months. The submental fat decreased by 20.54% at 1 month and by 30.37% at 3 months. The mean [standard deviation] volume reduction evaluated from 3D photography was 3.48 [3.60] mL immediately after the fourth treatment, 5.39 [5.93] mL at 1 month, and 10.25 [5.40] mL at 3 months. The mean Clinician-Reported Submental Fat Rating Scale grade improved by 0.56 [0.42] points after the fourth treatment, by 0.85 [0.53] points at 1 month, and by 1.03 [0.50] points at 3 months. Overall, 84.8% of subjects found the treatment comfortable and 93.9% were satisfied with the treatment results.
Conclusions: The study findings suggest that this novel approach offers a notable option for submental volume reduction, indicating that HIFES and Sync RF+ technology is capable of aesthetic enhancement as well as skin and muscle improvement.
© The Author(s) 2025. Published by Oxford University Press on behalf of The Aesthetic Society.