Abstract
Influenza A(H1N1)pdm09 virus carrying an I38N substitution was detected in an untreated teenager in Japan. The I38N mutant virus exhibited reduced susceptibility to baloxavir but remained susceptible to neuraminidase inhibitors and showed reduced growth capability. Monitoring antiviral drug susceptibility of influenza viruses is necessary to aid public health planning and clinical recommendations.
Keywords:
A(H1N1)pdm09; I38N substitution; Japan; antimicrobial resistance; baloxavir acid; baloxavir marboxil; cap-dependent endonuclease inhibitor; drug resistance; influenza; influenza virus; polymerase acidic protein; respiratory infections; viruses.
MeSH terms
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Acids, Carbocyclic
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Adolescent
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Antiviral Agents* / pharmacology
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Antiviral Agents* / therapeutic use
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Dibenzothiepins* / pharmacology
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Drug Resistance, Viral* / genetics
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Humans
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Influenza A Virus, H1N1 Subtype / drug effects
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Influenza A Virus, H1N1 Subtype / genetics
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Influenza, Human / drug therapy
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Influenza, Human / epidemiology
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Influenza, Human / virology
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Japan / epidemiology
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Microbial Sensitivity Tests
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Morpholines / pharmacology
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Neuraminidase / antagonists & inhibitors
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Oxazines* / pharmacology
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Pyridines* / pharmacology
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Pyridones* / pharmacology
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Thiepins / pharmacology
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Thiepins / therapeutic use
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Triazines / pharmacology
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Triazines / therapeutic use
Substances
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Acids, Carbocyclic
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Antiviral Agents
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baloxavir
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Dibenzothiepins
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Morpholines
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Neuraminidase
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Oxazines
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Pyridines
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Pyridones
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Thiepins
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Triazines