Thioridazine: a selective inhibitor of peroxisomal beta-oxidation in vivo

FEBS Lett. 1985 Aug 5;187(2):331-3. doi: 10.1016/0014-5793(85)81270-9.

Abstract

In vivo administration of the phenothiazine drug, thioridazine, inhibits hepatic peroxisomal beta-oxidation in mice. In starving animals, 3-hydroxybutyrate concentration is not decreased by thioridazine treatment. These results provide the first demonstration of thioridazine as a selective inhibitor of peroxisomal beta-oxidation in intact animals. Thioridazine might supply a tool for simulation of pathological conditions in which peroxisomal beta-oxidation is impaired.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3-Hydroxybutyric Acid
  • Animals
  • Catalase / metabolism
  • Fatty Acids / metabolism*
  • Hydrogen Peroxide / metabolism
  • Hydroxybutyrates / blood
  • Liver / drug effects*
  • Liver / metabolism
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Microbodies / drug effects*
  • Microbodies / metabolism
  • Thioridazine / pharmacology*

Substances

  • Fatty Acids
  • Hydroxybutyrates
  • Hydrogen Peroxide
  • Catalase
  • Thioridazine
  • 3-Hydroxybutyric Acid