Pyridoxine for neonatal seizures: an unexpected danger

Dev Med Child Neurol. 1985 Jun;27(3):377-9. doi: 10.1111/j.1469-8749.1985.tb04551.x.


A case of pyridoxine-dependent seizures is reported. Administration of pyridoxine to an infant after a long period of convulsions was followed by acute hypotonia. Other cases have been reported in the literature, in one of which assisted ventilation was required. A possible mechanism for this alarming outcome is discussed, and it is suggested that resuscitation facilities should be quickly available during such trials.

Publication types

  • Case Reports

MeSH terms

  • Electroencephalography
  • Evoked Potentials / drug effects
  • Humans
  • Infant, Newborn
  • Male
  • Muscle Hypotonia / chemically induced
  • Pyridoxine / adverse effects*
  • Pyridoxine / therapeutic use
  • Spasms, Infantile / drug therapy*


  • Pyridoxine