The clones have STRACK: Tracing responses to leukemic mutations

Eirini P Papapetrou

doi:10.1016/j.stem.2025.03.001

The clones have STRACK: Tracing responses to leukemic mutations

Cell Stem Cell. 2025 Apr 3;32(4):499-501. doi: 10.1016/j.stem.2025.03.001.

Author

Eirini P Papapetrou¹

Affiliation

¹ Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Institute of Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: eirini.papapetrou@mssm.edu.

PMID: 40185067
DOI: 10.1016/j.stem.2025.03.001

Abstract

Rodriguez-Fraticelli and colleagues combine genetic barcoding with ex vivo expansion and sister-cell analysis of murine hematopoietic stem cells (HSCs) carrying inducible leukemia driver mutations. This approach allows them to capture the intrinsic heterogeneity of clonal cell behaviors and study how these impact cell fates upon acquisition of leukemia driver mutations.

MeSH terms

Animals
Clone Cells / pathology
Hematopoietic Stem Cells* / metabolism
Hematopoietic Stem Cells* / pathology
Humans
Leukemia* / genetics
Leukemia* / pathology
Mice
Mutation* / genetics