Continuous gastric pH measurement in young and older healthy preterm infants receiving formula and clear liquid feedings

J Pediatr Gastroenterol Nutr. 1985 Jun;4(3):352-5. doi: 10.1097/00005176-198506000-00005.


Gastric pH was recorded with an intragastric pH electrode for 12 h in two groups of healthy, preterm infants with similar birth weights (range 1.4 to 2.0 kg). Group I infants (n = 13) were less than 7 days old and Group II infants (n = 10) were 7-15 days old. Infants were fed three formula feedings and one clear liquid feeding during the study. In Group I, mean gastric pH measured at 15-min intervals was above 4.0 for 3 h after either feeding. In Group II mean gastric pH was lower particularly after clear liquid feedings, where it remained below pH 4.0 for the entire 3-h postprandial period. The percent of monitored time at gastric pH less than 4.0 was low in Group I--15.2 +/- 4.2% and 20.6 +/- 6.4% after formula and clear liquid, respectively. The percent time was greater in Group II--42.7 +/- 8.0% and 61.9 +/- 7.3% after formula and clear liquid, respectively. In the younger preterm infant, gastric pH does not appear sufficiently low to support peptic activity.

MeSH terms

  • Age Factors
  • Gastric Acid / metabolism
  • Humans
  • Hydrogen-Ion Concentration
  • Infant Food*
  • Infant, Newborn
  • Infant, Premature*
  • Stomach*