Pharmacokinetics of theobromine and its metabolites in rabbits

J Pharmacokinet Biopharm. 1985 Feb;13(1):41-53. doi: 10.1007/BF01073655.

Abstract

The pharmacokinetics of theobromine (3, 7-DMX) and its metabolites was investigated in detail in four male rabbits after bolus intravenous injection (4 mg/kg) of the compound. Apparent first-order rate constants for the metabolic processes involved in the formation of 3,7-DMX metabolites and their excretion in urine were calculated. Theobromine, 7-methylxanthine (7-MX) and 3-methylxanthine (3-MX) were measured in blood and urine, and the other metabolites were determined only in urine. An appropriate model of 14 compartments is formulated to describe the disposition of 3,7-DMX and its metabolites.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biotransformation
  • Chromatography, High Pressure Liquid
  • Kinetics
  • Male
  • Rabbits
  • Theobromine / blood
  • Theobromine / metabolism*
  • Theobromine / urine
  • Time Factors

Substances

  • Theobromine