Sustained release of cytokines from migrasomes

Yan Zhen; Harald Stenmark

doi:10.20517/evcna.2025.15

Sustained release of cytokines from migrasomes

Extracell Vesicles Circ Nucl Acids. 2025 Mar 20;6(1):171-175. doi: 10.20517/evcna.2025.15. eCollection 2025.

Authors

Yan Zhen^{1

2}, Harald Stenmark^{1

2}

Affiliations

¹ Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Oslo 0379, Norway.
² Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Oslo 0379, Norway.

Abstract

Cytokines are released by cells in response to infections and tissue damage. A recent paper by Jiao et al. demonstrates that circulating monocytes release the cytokines tumor necrosis factor and Interleukin-6 encapsulated in large extracellular vesicles called migrasomes, from which the cytokines are secreted locally in a sustained fashion.

Keywords: Cytokine; extracellular vesicles; inflammation; interleukin; migrasome; monocyte.