Action and localization of glycine and taurine in the cat retina

J Physiol. 1985 May;362:395-413. doi: 10.1113/jphysiol.1985.sp015685.

Abstract

The effects on retinal ganglion cells of iontophoretically applied glycine, taurine and strychnine were studied in the optically intact eye of the cat. Glycine and taurine suppressed the light-evoked discharge of all on-centre and off-centre brisk ganglion cells, regardless of the visual stimulus used. Strychnine blocked the action of externally applied glycine and taurine. The light-evoked response of all ganglion cells was raised by strychnine. The tonic discharge of the light response was suppressed or raised by the drugs more than the phasic response. A population of amacrine cells, which was heavily labelled by [3H]glycine, did not take up [3H]taurine. [3H]taurine was only weakly accumulated by inner nuclear layer neurones and was predominantly located in the outer retina.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects
  • Animals
  • Autoradiography
  • Cats
  • Glycine / metabolism
  • Glycine / pharmacology*
  • In Vitro Techniques
  • Photic Stimulation
  • Retina / drug effects*
  • Retina / metabolism
  • Retinal Ganglion Cells / drug effects
  • Strychnine / pharmacology
  • Taurine / metabolism
  • Taurine / pharmacology*

Substances

  • Taurine
  • Strychnine
  • Glycine