Mucosal stargazing: IgA keeps astrovirus in check

Cell Host Microbe. 2025 Apr 9;33(4):457-458. doi: 10.1016/j.chom.2025.02.009.

Abstract

Immunoglobulin A (IgA) antibodies maintain homeostasis between the host and its microbiota, by exerting luminal control over fungi and bacteria. In this issue of Cell Host & Microbe, Lisicka et al. show that IgA antibodies also control the population of specific members of our virome.

MeSH terms

  • Animals
  • Antibodies, Viral* / immunology
  • Astroviridae Infections* / immunology
  • Astroviridae Infections* / virology
  • Astroviridae* / immunology
  • Gastrointestinal Microbiome / immunology
  • Humans
  • Immunoglobulin A* / immunology
  • Mamastrovirus* / immunology
  • Virome / immunology

Substances

  • Immunoglobulin A
  • Antibodies, Viral