Clinical Characteristics and Treatment of Histiocytic Disorders in Children

Barbara A Degar; Jennifer T Huang; Jacob Bledsoe

doi:10.1016/j.hoc.2025.02.006

Clinical Characteristics and Treatment of Histiocytic Disorders in Children

Hematol Oncol Clin North Am. 2025 Apr 9:S0889-8588(25)00024-3. doi: 10.1016/j.hoc.2025.02.006. Online ahead of print.

Authors

Barbara A Degar¹, Jennifer T Huang², Jacob Bledsoe³

Affiliations

¹ Department of Pediatrics, Harvard Medical School, Boston, MA 02215, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute / Boston Children's Cancer and Blood Disease Center, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address: Barbara_Degar@dfci.harvard.edu.
² Department of Dermatology, Harvard Medical School, Boston, MA 02215, USA; Division of Immunology, Department of Dermatology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02215, USA.
³ Department of Pathology, Harvard Medical School, Boston, MA 02215, USA; Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02215, USA.

PMID: 40210506
DOI: 10.1016/j.hoc.2025.02.006

Abstract

Several distinct histiocytic neoplasms occur in children. These diseases are rare and their behavior is remarkably variable. In this article, the clinical and histopathologic features of Langerhans cell histiocytosis, Juvenile Xanthogranuloma, Rosai-Dorfman-Destombes, and ALK + Histiocytosis are reviewed. Recommendations for diagnostic evaluation of these entities are included and treatment approaches are presented.

Keywords: ALK+ histiocytosis; Histiocytosis; Juvenile xanthogranuloma; Langerhans cell histiocytosis; Rosai-Dorfman-Destombes.

Publication types

Review