Abstract
The metabolism of unsaturated bile acids and androstanes by mixed human faecal cultures has been studied. The reactions observed were mainly reductive. Unsaturated 4-ene-3-oxo and 1,4-diene-3-oxo bile acids were reduced in Ring A. 5 beta-3-Oxo bile acids were reduced to 5 beta-3-hydroxy bile acids. 4-Ene, 1,4-diene and 4,6-diene-3,17-dioxo-androstanes were reduced in Ring A with concomitant reduction of oxo groups to hydroxyl groups. The Gram-negative facultative anaerobic faecal bacteria are implicated in the reductive process, whilst the genus Clostridium does not appear to be important. Inclusion of menadione, a synthetic form of vitamin K, retards the reductive process.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Androstadienes / metabolism
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Androstanes / metabolism*
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Androstenedione / analogs & derivatives
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Androstenedione / metabolism
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Bacteria / metabolism*
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Bile Acids and Salts / metabolism*
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Deoxycholic Acid / analogs & derivatives
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Deoxycholic Acid / metabolism
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Feces / microbiology*
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Humans
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Lithocholic Acid / analogs & derivatives
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Lithocholic Acid / metabolism
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Oxidation-Reduction
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Pregnadienes / metabolism
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Vitamin K / pharmacology
Substances
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Androstadienes
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Androstanes
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Bile Acids and Salts
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Pregnadienes
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Deoxycholic Acid
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Vitamin K
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3-oxochol-4-en-24-oic acid
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12-hydroxyandrosta-1,4-diene-3,17-dione
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dehydrodeoxycholic acid
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Androstenedione
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Lithocholic Acid
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4,6-androstadiene-3,17-dione
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12-hydroxy-3-oxo-1,4-pregnadiene-20-carboxylic acid
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3-oxocholan-24-oic acid