Cholagogic effect of ginger and its active constituents

J Ethnopharmacol. 1985 May;13(2):217-25. doi: 10.1016/0378-8741(85)90009-1.


The effect of bile secretion in rats was examined in order to clarify the stomachic action of ginger and also to investigate its active constituents. The results showed that mainly the acetone extracts of ginger, which contain essential oils and pungent principles, caused an increase in the bile secretion. Further analyses for the active constituents of the acetone extracts through column chromatography indicated that [6]-gingerol and [10]-gingerol, which are the pungent principles, are mainly responsible for the cholagogic effect of ginger.

MeSH terms

  • Animals
  • Bile / metabolism
  • Catechols
  • Cholagogues and Choleretics*
  • Condiments*
  • Fatty Alcohols / pharmacology
  • Male
  • Plant Extracts / analysis
  • Plant Extracts / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Time Factors


  • Catechols
  • Cholagogues and Choleretics
  • Fatty Alcohols
  • Plant Extracts
  • gingerol