Abstract
Acrylophenone derivatives with in vitro antimicrotubular activities very similar to those of colchicine were tested on Triton WR 1339-induced hyperlipidemia in rats. They exhibit high normolipemic activity on plasmatic apolipoproteins AI and B, contrasting with inactivity on plasmatic lipids and lipoproteins.
MeSH terms
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Acrylates / pharmacology*
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Acrylates / therapeutic use
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Animals
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Apolipoproteins / blood
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Cholesterol / blood
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Hyperlipidemias / chemically induced
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Hyperlipidemias / drug therapy*
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Hypolipidemic Agents*
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Ketones / pharmacology*
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Ketones / therapeutic use
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Male
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Microtubules / drug effects*
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Phospholipids / blood
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Polyethylene Glycols
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Rats
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Structure-Activity Relationship
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Triglycerides / blood
Substances
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Acrylates
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Apolipoproteins
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Hypolipidemic Agents
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Ketones
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Phospholipids
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Triglycerides
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Polyethylene Glycols
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Cholesterol