Plasmapheresis and acute Guillain-Barré syndrome. The Guillain-Barré syndrome Study Group

Neurology. 1985 Aug;35(8):1096-104.


We compared plasmapheresis with conventional therapy in 245 patients with the Guillain-Barré syndrome of recent onset. Statistically significant differences, favoring the plasmapheresis group, were found in terms of improvement at 4 weeks, time to improve one clinical grade, time to independent walking, and outcome at 6 months. Plasmapheresis was not effective for all patients, but was particularly effective for patients who received this treatment within 7 days of onset and for patients who required mechanical ventilation after entry into the study. Plasmapheresis appears to be of benefit in patients with Guillain-Barré syndrome of recent onset.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acute Disease
  • Aged
  • Evaluation Studies as Topic
  • Humans
  • Middle Aged
  • Plasmapheresis* / adverse effects
  • Polyradiculoneuropathy / mortality
  • Polyradiculoneuropathy / therapy*
  • Random Allocation
  • Recurrence
  • Respiration, Artificial
  • Time Factors