Unveiling the neural network involved in mentally projecting the self through episodic autobiographical memories

Abstract

Episodic autobiographical memory involves the ability to travel along the mental timeline, so that events of our own life can be recollected and re-experienced. In the present study, we tested the neural underpinnings of mental travel across past and future autobiographical events by using a spatiotemporal interference task. Participants were instructed to mentally travel across past and future personal (Episodic Autobiographical Memories; EAMs) and Public Events (PEs) during Functional Magnetic Resonance Imaging (fMRI). We found that a distributed network of brain regions (i.e., occipital, temporal, parietal, frontal, and subcortical regions) is implicated in mental projection across past and future independently from the memory category (EAMs or PEs). Interestingly, we observed that most of these regions exhibited a neural modulation as a function of the lifetime period and/or as a function of the compatibility with a back-to-front mental timeline, specifically for EAMs, indicating the key role of these regions in representing the temporal organization of personal but not public events. Present findings provide insights into how personal events are temporally organized within the human brain.

Keywords: Autobiographical memory; Functional magnetic resonance (fMRI); Mental timeline; Psychophysiological interaction (PPI)..