Investigating renal function during lithium treatment

Psychol Med. 1985 May;15(2):369-75.


The tests that have been used to assess glomerular and tubular function in patients receiving treatment with lithium have been reviewed. The advantages and disadvantages of these are discussed. The most useful tests are the creatinine clearance, which may be predicted from the serum creatinine using a formula or nomogram, and the measurement of urine osmolality, followed if necessary by assessment of the maximum urine concentrating ability after desamino cys-1-8-D arginine vasopressin.

MeSH terms

  • Acetylglucosaminidase / urine
  • Acid-Base Equilibrium / drug effects
  • Bipolar Disorder / drug therapy*
  • Glomerular Filtration Rate / drug effects
  • Humans
  • Hydrogen-Ion Concentration
  • Kidney / drug effects*
  • Kidney Concentrating Ability
  • Kidney Function Tests*
  • Lithium / adverse effects*
  • Lithium / therapeutic use
  • Proteinuria / chemically induced


  • Lithium
  • Acetylglucosaminidase