Cytology-Radiology Correlation Series: Pancreatic cytopathology

Cancer Cytopathol. 2025 May;133(5):e70012. doi: 10.1002/cncy.70012.

Abstract

The prevalence of pancreatic lesions has increased over the years because of an increase in accessibility to and the quality of cross-sectional imaging. This commentary describes the common non-neoplastic and neoplastic pancreatic lesions. The images in this commentary depict classic cross-sectional images, sonographic findings, and the cytopathologic diagnosis of each lesion. Most common non-neoplastic lesions include pseudocysts, autoimmune pancreatitis, and chronic pancreatitis. Most common neoplastic lesions include serous cystadenomas, intraductal papillary mucinous neoplasms, mucinous cystic neoplasms, solid pseudopapillary neoplasms, neuroendocrine tumors, pancreatic ductal adenocarcinoma, acinar cell carcinoma, and metastases to the pancreas. The aim of this Cytoimaging Correlation Series is to demonstrate the multidisciplinary involvement in the diagnosis of pancreatic pathology and to highlight main findings in the most common entities found in everyday practice.

Keywords: cytopathology; endoscopic ultrasound (EUS); endoscopy; imaging; pancreatic cytopathology.

Publication types

  • Review

MeSH terms

  • Cytodiagnosis* / methods
  • Humans
  • Pancreas* / diagnostic imaging
  • Pancreas* / pathology
  • Pancreatic Neoplasms* / diagnosis
  • Pancreatic Neoplasms* / diagnostic imaging
  • Pancreatic Neoplasms* / pathology