Prefrontal cortex modulation of stress by primary cilia

Shixiong Tian; Joseph G Gleeson

doi:10.1016/j.neuron.2025.03.026

Prefrontal cortex modulation of stress by primary cilia

Neuron. 2025 Apr 16;113(8):1126-1128. doi: 10.1016/j.neuron.2025.03.026.

Authors

Shixiong Tian¹, Joseph G Gleeson²

Affiliations

¹ Laboratory for Pediatric Brain Disease, Rady Children's Institute for Genomic Medicine, University of California, San Diego, San Diego, CA 92037, USA.
² Laboratory for Pediatric Brain Disease, Rady Children's Institute for Genomic Medicine, University of California, San Diego, San Diego, CA 92037, USA. Electronic address: jogleeson@health.ucsd.edu.

PMID: 40245842
DOI: 10.1016/j.neuron.2025.03.026

Abstract

In this issue of Neuron, Yang et al.¹ reveal that primary cilia in mouse prefrontal cortex excitatory neurons regulate stress responses via cAMP/PKA signaling. Stress induces ciliary elongation, enhancing corticosterone-mediated neuronal inhibition. Cilia loss reduces stress sensitivity, highlighting their role in stress adaptation, with potential therapeutic relevance.

Publication types

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MeSH terms

Animals
Cilia* / physiology
Mice
Neurons* / physiology
Prefrontal Cortex* / cytology
Prefrontal Cortex* / physiology
Signal Transduction / physiology
Stress, Physiological* / physiology
Stress, Psychological* / physiopathology