Coilin Is Not Expressed by Immunohistochemistry in Hodgkin and Diffuse Large B-cell Lymphomas

Appl Immunohistochem Mol Morphol. 2025 Jul 1;33(4):264-265. doi: 10.1097/PAI.0000000000001259. Epub 2025 Apr 21.

Abstract

Coilin is the signature protein of Cajal bodies (CBs), membrane-less organelles probably acting as sites for post-transcriptional RNA modification. Recent data suggest that coilin may be a regulator of the NF-kB activity, and Hodgkin lymphomas are hallmarks of neoplasms with NF-kB dysregulation. To the best of our knowledge, the immunohistochemical expression of coilin has been never investigated in Hodgkin lymphomas. We herein examined, by immunohistochemistry, full tissue sections of 58 classical Hodgkin lymphomas diagnosed in 31 male and 27 female patients and found that none of the cases expressed coilin. We compared these findings with Coilin expression in diffuse large B-cell lymphomas (DLBCL), where the marker was also negative. This finding represents the first data on coilin in lymphomas and prompts further studies to explore this downregulation.

Keywords: Cajal body; cancer; coilin; immunohistochemistry; lymphoma; nucleolus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biomarkers, Tumor
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Hodgkin Disease* / diagnosis
  • Hodgkin Disease* / metabolism
  • Hodgkin Disease* / pathology
  • Humans
  • Immunohistochemistry
  • Lymphoma, Large B-Cell, Diffuse* / diagnosis
  • Lymphoma, Large B-Cell, Diffuse* / metabolism
  • Lymphoma, Large B-Cell, Diffuse* / pathology
  • Male
  • Middle Aged
  • Nuclear Proteins* / biosynthesis
  • Nuclear Proteins* / metabolism

Substances

  • Nuclear Proteins
  • Biomarkers, Tumor