The present study assessed the effects of a metacognitive strategy-guided health management model on vascular endothelial function and quality of life in patients with hypertension and hyperlipidemia. Patient self-management ability, such as medication adherence, rational diet, and moderate exercise, before and after management was assessed by questionnaire (36-Item Short Form Health Survey, SF-36). Total cholesterol (TC), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and blood pressure (BP) were compared. Vascular endothelial function was evaluated: Serum levels of endothelin-1 (ET-1) were measured by radioimmunoassay, and serum levels of nitric oxide (NO) were measured by a nitrate reduction method. Quality of life after management was assessed by the SF-36. The observation group (implementation of metacognitive strategy-guided health management) had higher self-management ability scores, lower lipid indicators, lower systolic and diastolic BP, decreased ET-1 and higher NO levels, and greater quality of life scores than the control group (no health management; all P < .05). Metacognitive strategy-guided health management model can improve vascular endothelial function and enhances quality of life in patients with hypertension and hyperlipidemia.
Keywords: health management; hyperlipidemia; hypertension; metacognitive strategy guidance; quality of life; vascular endothelial function.