Detection of Sub-acute Brain Injury and Hypoxic-ischemic Encephalopathy using I2C2-WGO and CO-GW-RNN

Curr Med Imaging. 2025:21:e15734056352573. doi: 10.2174/0115734056352573241118122026.

Abstract

Background: Hypoxic-ischemic encephalopathy (HIE) is a brain injury that is caused by improper oxygen/blood flow. None of the existing works have concentrated on detecting HIE based on the sub-acute injury in the brain.

Objective: To enhance the accuracy and specificity of HIE detection, a comprehensive approach that includes SAI identification, BGT segmentation, and volume calculation will be utilized.

Methods: This study addresses the critical challenge of detecting hypoxic-schemic encephalopathy (HIE) through advanced image processing techniques applied to brain MRI data. The primary research questions focus on the effectiveness of the proposed CO-GW-RNN method in accurately identifying HIE and the impact of incorporating segmentation and clustering processes on detection performance.

Results: The proposed method achieved remarkable results, demonstrating an accuracy of 98.98% and a specificity of 98.17%, significantly outperforming existing techniques such as the RUB classifier (84.6% accuracy) and the DTL method (94.00% accuracy).

Conclusion: These findings validate the effectiveness of the proposed methodology in improving HIE detection in brain MRI images.

Keywords: Brain MRI; Brain injury; Gadolinium enhancement pattern; Internal capsule; Recurrent neural network; Wild geese optimization..

MeSH terms

  • Algorithms
  • Brain / diagnostic imaging
  • Brain Injuries* / diagnostic imaging
  • Female
  • Humans
  • Hypoxia-Ischemia, Brain* / diagnostic imaging
  • Image Processing, Computer-Assisted* / methods
  • Magnetic Resonance Imaging* / methods
  • Male
  • Sensitivity and Specificity