Primary myeloproliferative disorder and hepatic vein thrombosis. A prospective study of erythroid colony formation in vitro in 20 patients with Budd-Chiari syndrome

Ann Intern Med. 1985 Sep;103(3):329-34. doi: 10.7326/0003-4819-103-3-329.


We assessed the prevalence of overt and latent primary myeloproliferative disorders in hepatic vein thrombosis. Cultures of bone marrow or peripheral blood mononuclear cells were done in 20 patients with Budd-Chiari syndrome. Erythroid colony formation in the absence of erythropoietin, which is a reliable indicator for a primary myeloproliferative disorder, was seen in 16 patients in whom Budd-Chiari syndrome was due to hepatic vein thrombosis, including 13 women aged 18 to 45 years. Among these 16 patients, the conventional criteria for the diagnosis of a primary myeloproliferative disorder were met in only 2. Primary myeloproliferative disorder, often without peripheral blood changes, is a major cause of hepatic vein thrombosis in young women.

MeSH terms

  • Adolescent
  • Adult
  • Budd-Chiari Syndrome / blood
  • Budd-Chiari Syndrome / etiology*
  • Colony-Forming Units Assay
  • Contraceptives, Oral
  • Erythrocyte Volume
  • Erythropoiesis*
  • Erythropoietin / blood
  • Female
  • Hematopoietic Stem Cells / cytology
  • Humans
  • Male
  • Middle Aged
  • Myeloproliferative Disorders / complications*
  • Polycythemia Vera / complications
  • Prospective Studies


  • Contraceptives, Oral
  • Erythropoietin