Nuage in color: Systematic protein tagging shows the compositional complexity of germ granules

Laura L Thomas; Devavrat M Bodas; Geraldine Seydoux

doi:10.1016/j.devcel.2025.03.015

Nuage in color: Systematic protein tagging shows the compositional complexity of germ granules

Dev Cell. 2025 Apr 21;60(8):1135-1137. doi: 10.1016/j.devcel.2025.03.015.

Authors

Laura L Thomas¹, Devavrat M Bodas², Geraldine Seydoux²

Affiliations

¹ HHMI and Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: tlaura2@jhmi.edu.
² HHMI and Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

PMID: 40262523
DOI: 10.1016/j.devcel.2025.03.015

Abstract

In this issue of Developmental Cell, Huang et al. generate a library of C. elegans strains to systematically characterize germ granule composition. This survey catalogs condensate proteins in an intact organism using endogenous tags and sets the stage for future studies of condensate composition and function.

Publication types

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MeSH terms

Animals
Caenorhabditis elegans Proteins* / genetics
Caenorhabditis elegans Proteins* / metabolism
Caenorhabditis elegans* / genetics
Caenorhabditis elegans* / metabolism
Cytoplasmic Granules* / metabolism
Germ Cells* / metabolism

Substances

Caenorhabditis elegans Proteins