Human medial temporal-lobe stimulation disrupts both formation and retrieval of recent memories

Brain Cogn. 1985 Jul;4(3):287-95. doi: 10.1016/0278-2626(85)90022-3.


Disrupting medial temporal-lobe (MTL) activity for less than a second, either during the initial presentation of a complex scene or when it is presented again 1 min later, severely impairs recognition at the second presentation. MTL disruption during both presentation and recognition periods produces further impairment. These results are not consistent with views limiting MTL function solely to encoding or solely to retrieval mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amygdala / physiology
  • Electric Stimulation
  • Hippocampus / physiology
  • Humans
  • Memory, Short-Term / physiology*
  • Mental Recall / physiology
  • Neural Pathways / physiology
  • Retention, Psychology / physiology
  • Temporal Lobe / physiology*