Sex-specific difference of the galabiosylceramide level in the glycosphingolipids of human thyroid

Biochim Biophys Acta. 1985 Aug 22;836(1):143-52. doi: 10.1016/0005-2760(85)90230-9.

Abstract

The glycosphingolipids of human thyroid were isolated and characterized by gas-liquid chromatography and sequential enzymic hydrolysis. The major purified components were identified as glucosyl- and galactosyl-ceramides, lactosyl- and galabiosylceramides, globotriaosyl- and globotetraosylceramides. The long-chain base analyses showed a high proportion of phytosphingosine in glycosylceramide and galabiosylceramide. Fatty acids in 22:0, 24:0, 24:1 prevailed, especially in the cerebroside fraction, with a significant content of alpha-hydroxylated species in galactosylceramide. Female thyroid had a very low content of galabiosylceramide and a higher content of glucosylceramide, as compared to male. No significant difference was found in the other neutral glycosphingolipids and gangliosides.

MeSH terms

  • Carbohydrates / analysis
  • Cerebrosides / analysis*
  • Chromatography, Gas
  • Chromatography, Thin Layer
  • Densitometry
  • Fatty Acids / analysis
  • Female
  • Glycosphingolipids / analysis*
  • Humans
  • Male
  • Sex Characteristics*
  • Thyroid Gland / analysis*

Substances

  • Carbohydrates
  • Cerebrosides
  • Fatty Acids
  • Glycosphingolipids