[Lipid peroxidation in the myocardium in experimental infarct]

Nauchnye Doki Vyss Shkoly Biol Nauki. 1985;(5):30-3.
[Article in Russian]

Abstract

Changes in the content of lipid peroxidation (LP) products and activities of antioxidant enzymes--superoxide dismutase, glutathione peroxidase and catalase in myocardium of rats after experimental infarction as well as after pretreatment with antioxidant ionol, beta-adrenoblocker inderal and verapamil, an inhibitor of slow Ca2+-channels have been studied. In the left ventricles of the control animals decreased levels of LP-products (Schiff bases and lipid hydroperoxides) have been registered as compared with right ventricles, accompanied by increased activity of antioxidant enzymes in the left ventricles. In experimental infarction the level of LP products increases and activity of antioxidant enzymes decreases both in ischemic and nonischemic regions of the heart. In nonischemic zone these changes can be prevented by pretreatment with inderal and ionol but not with verapamil.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Butylated Hydroxytoluene / therapeutic use
  • Catalase / metabolism
  • Drug Evaluation, Preclinical
  • Glutathione Peroxidase / metabolism
  • Lipid Peroxides / metabolism*
  • Male
  • Myocardial Infarction / drug therapy
  • Myocardial Infarction / metabolism*
  • Myocardium / metabolism*
  • Oxidation-Reduction / drug effects
  • Propranolol / therapeutic use
  • Rats
  • Superoxide Dismutase / metabolism
  • Verapamil / therapeutic use

Substances

  • Lipid Peroxides
  • Butylated Hydroxytoluene
  • Propranolol
  • Verapamil
  • Catalase
  • Glutathione Peroxidase
  • Superoxide Dismutase