HERmione: Understanding the Needs of Patients Living with Metastatic HER2-Positive Breast Cancer Through a Cross-Sectional Survey in Parallel with Patients and Oncologists

Cancers (Basel). 2025 Apr 17;17(8):1349. doi: 10.3390/cancers17081349.

Abstract

Background/objectives: HER2-positive metastatic breast cancer continues to have a significant impact on patients' lives. The HERmione project was conducted in France to identify patients' needs for support and information, understand services offered, and identify differences in the perception of burden between patients and oncologists.

Methods: Between July and October 2022, 273 patients with HER2-positive metastatic breast cancer and 40 oncologists were surveyed. The mean age of patients was 52 years, with most receiving treatment at specialized cancer centers (38%) or other public hospitals (34%).

Results: The survey revealed a substantial burden of the disease and treatment in patients, perceptions that differed from those of oncologists. Both the physical and mental well-being of the patients were below average. Despite the burden of the disease, patients lacked access to many types of support, particularly support with sexual well-being. Additionally, 60% of patients did not have access to nursing support. Patients had high expectations regarding access to information but often did not know where to access this information. Despite this, they still exhibited treatment preferences.

Conclusions: These findings suggest that enhanced communication is critical to ensure that patients receive adequate support. Nursing support could improve patient-oncologist communication and thereby enhance patient well-being. Finally, to meet patient expectations regarding information access, a broader array of support tools should be offered.

Keywords: breast cancer; clinician-reported outcomes; oncology; patient-reported outcomes; quality of life; support needs; treatment preferences.

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