Exploring Socio-Behavioral Correlates of Metabolic and Inflammatory Risk in a University Sample Residing Along the U.S./Mexico Border: A Pilot Study Concomitantly Collecting Survey Data, Blood and Hair Samples, and Physical Measures

Int J Environ Res Public Health. 2025 Apr 20;22(4):647. doi: 10.3390/ijerph22040647.

Abstract

Hispanic adults have an increased incidence of type 2 diabetes (T2D) at a younger age and diagnosis of certain cancers, including liver, stomach, and colorectal, which may be attributed to metabolic health. Several key metabolic health indicators, such as hemoglobin A1c (HbA1c), body mass index (BMI), and waist-to-hip ratio (WHR), have been linked to obesity. The purpose of this pilot study was to explore the complex relationships between socio-behavioral factors that lead to the increased incidence of metabolic syndrome (e.g., HbA1c) and chronic inflammation (interleukins) in Hispanics. Two hundred and twelve Hispanic participants (Mage = 43.45, SD = 15.36) who identified predominantly as female (72.17%) were included in the study. Correlational analyses revealed that HbA1c was positively associated with age and negatively associated with several socio-behavioral factors, including overall health, quality of life, physical health, physical performance, social support, mother's education, and father's education. These findings highlight the importance of social support and parental involvement in diabetes management. The focused integration of socio-behavioral and biological data provides a powerful foundation for future research and the development of targeted interventions.

Keywords: HbA1c; Hispanic; body mass index; diabetes; inflammation.

MeSH terms

  • Adult
  • Aged
  • Body Mass Index
  • Diabetes Mellitus, Type 2* / diagnosis
  • Diabetes Mellitus, Type 2* / epidemiology
  • Diabetes Mellitus, Type 2* / ethnology
  • Female
  • Glycated Hemoglobin / analysis
  • Hair / chemistry
  • Hispanic or Latino* / statistics & numerical data
  • Humans
  • Inflammation* / diagnosis
  • Inflammation* / epidemiology
  • Inflammation* / ethnology
  • Male
  • Metabolic Syndrome* / diagnosis
  • Metabolic Syndrome* / epidemiology
  • Metabolic Syndrome* / ethnology
  • Mexico / ethnology
  • Middle Aged
  • Pilot Projects
  • Risk Factors
  • United States / epidemiology
  • United States / ethnology
  • Universities / statistics & numerical data

Substances

  • Glycated Hemoglobin