Single dose dexamethasone suppression test in children: dose relationship to body size

Clin Endocrinol (Oxf). 1985 Jul;23(1):67-70. doi: 10.1111/j.1365-2265.1985.tb00184.x.


We have performed an overnight single dose dexamethasone suppression test in 15 children at different dosages to determine the minimum dose required to suppress the 0800 h serum cortisol level. With a dexamethasone dose of 0.1 mg/m2 two of seven children showed suppression. When the dose was increased to 0.3 mg/m2 all of six patients showed suppression as did three given dexamethasone 0.5 mg/m2. We recommend that doses of dexamethasone should be calculated in terms of body surface area when assessing the hypothalamo-pituitary axis in children and that a dose of 0.3 mg/m2 should be used for suppression tests.

MeSH terms

  • Body Surface Area
  • Child
  • Cushing Syndrome / blood
  • Cushing Syndrome / diagnosis*
  • Depression, Chemical
  • Dexamethasone / administration & dosage*
  • Female
  • Humans
  • Hydrocortisone / blood*
  • Male


  • Dexamethasone
  • Hydrocortisone