Possible mechanisms of hydrocarbon-associated glomerulonephritis

Clin Nephrol. 1985 Jun;23(6):294-8.

Abstract

Many hydrocarbons have properties which make them candidates for causing glomerulonephritis. They alter most immune functions and create a state of immunity deficiency; they damage the tubules which may lead to interstitial fibrosis and increased postglomerular capillary resistance furthering the trapping of macromolecules in the glomeruli; and they probably increase tissue permeability to macromolecules. The idea that hydrocarbons cause glomerulonephritis is supported by findings of an association between glomerulonephritis and hydrocarbon exposure, by findings of a relationship between tubulointerstitial damage and glomerular filtration rate in glomerulonephritis, and by findings of immunity deficiency in most subgroups of glomerulonephritis.

MeSH terms

  • Animals
  • Dermatitis, Contact / etiology
  • Glomerulonephritis / chemically induced*
  • Glomerulonephritis / immunology
  • Humans
  • Hydrocarbons / adverse effects*
  • Hydrocarbons / poisoning
  • Hydrocarbons / toxicity
  • Immunity / drug effects
  • Immunocompetence / drug effects
  • Kidney Tubules / drug effects
  • Mice
  • Occupational Diseases / chemically induced*
  • Rabbits
  • Rats

Substances

  • Hydrocarbons