Comparative randomized study of cerebral blood flow after long-term administration of pentoxifylline and co-dergocrine mesylate in patients with chronic cerebrovascular disease

Curr Med Res Opin. 1985;9(7):475-9. doi: 10.1185/03007998509109621.


The behaviour of regional cerebral blood flow was studied in 90 patients with vascular type dementia. Patients were divided at random into three groups of 30 and treated 3-times daily over a period of 8 weeks with either 400 mg pentoxifylline ('Trental' 400) or 2 mg co-dergocrine mesylate, or remained untreated (control group). Measurements of regional cerebral blood flow were made before and after 4 and 8 weeks of the study using an atraumatic inhalative 133Xenon clearance technique and assessments made in 16 regions of interest per hemisphere (grey matter perfusion). A statistically significant increase over baseline in mean regional cerebral blood flow was found in patients on pentoxifylline medication at Weeks 4 and 8. At Week 8, the change from baseline was +16.4% in the pentoxifylline group whereas the respective values for the other two groups were +0.4% for co-dergocrine mesylate, -2.4% for the controls. Hypoemic regions showed the most pronounced regional cerebral blood flow changes with pentoxifylline (+40%), the corresponding values for the co-dergocrine mesylate and control group being +10.8% and +0.4%, respectively.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Blood Flow Velocity
  • Cerebrovascular Circulation / drug effects*
  • Dementia / diagnostic imaging
  • Dementia / drug therapy*
  • Dihydroergotoxine / administration & dosage*
  • Dihydroergotoxine / adverse effects
  • Dihydroergotoxine / therapeutic use
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pentoxifylline / administration & dosage*
  • Pentoxifylline / adverse effects
  • Pentoxifylline / therapeutic use
  • Radionuclide Imaging
  • Random Allocation
  • Regional Blood Flow / drug effects
  • Theobromine / analogs & derivatives*
  • Time Factors
  • Xenon Radioisotopes


  • Xenon Radioisotopes
  • Dihydroergotoxine
  • Theobromine
  • Pentoxifylline