Generation of reactive metabolites of N-hydroxy-phenacetin by glucoronidation and sulfation

Biochem Pharmacol. 1977 Feb 1;26(3):189-96. doi: 10.1016/0006-2952(77)90301-x.
No abstract available

MeSH terms

  • Acetamides / metabolism
  • Animals
  • Glucuronates / metabolism
  • Glucuronosyltransferase / metabolism
  • In Vitro Techniques
  • Kinetics
  • Liver / metabolism
  • Male
  • Phenacetin / analogs & derivatives*
  • Phenacetin / chemical synthesis
  • Phenacetin / metabolism
  • Phenacetin / pharmacology
  • Protein Binding
  • Rats
  • Structure-Activity Relationship
  • Sulfates / metabolism
  • Sulfurtransferases / metabolism
  • Temperature
  • Time Factors

Substances

  • Acetamides
  • Glucuronates
  • Sulfates
  • Glucuronosyltransferase
  • Sulfurtransferases
  • Phenacetin