Segregation analysis of ocular refraction and myopia

Hum Hered. 1985;35(4):232-9. doi: 10.1159/000153551.


Segregation analysis of ocular spherical refraction data using a unified model resulted in rejection of a Mendelian hypothesis of genetic transmission in nuclear families of both Japanese and European ancestries. Similar analyses of families which included at least 1 myope gave no evidence for the hypothesis that myopia is determined in part by a major gene. Most of the variation associated with ocular refraction, or with myopia, seems to be nongenetic in origin.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Humans
  • Myopia / genetics*
  • Pedigree
  • Refractive Errors / genetics*