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, 38 (7), 920-5

Specific Inhibition of glyceraldehyde-3-phosphate Dehydrogenase by Koningic Acid (Heptelidic Acid)

Specific Inhibition of glyceraldehyde-3-phosphate Dehydrogenase by Koningic Acid (Heptelidic Acid)

A Endo et al. J Antibiot (Tokyo).

Abstract

A sesquiterpene named koningic acid has been isolated from a strain of Trichoderma koningii as a potent inhibitor of ATP generation in the glycolytic pathway. From experiments with both cultured mouse carcinoma FM3A cells and isolated enzymes, it was shown that koningic acid is a specific inhibitor of glyceraldehyde 3-phosphate dehydrogenase that catalyzes the conversion of glyceraldehyde 3-phosphate to 3-phosphoglycerate.

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