Discovery research in physiologically maintained deceased

Science. 2025 May;388(6746):473-476. doi: 10.1126/science.adt3527. Epub 2025 May 1.

Authors

Douglas B Pet^{1

2}, Brendan Parent³, Neel S Singhal^{1

2}, Claire D Clelland^{1

4}

Affiliations

¹ Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
² Department of Neurology, Zuckerberg San Francisco General Hospital, University of California, San Francisco, CA, USA.
³ Division of Medical Ethics, Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
⁴ Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA, USA.

PMID: 40310922
PMCID: PMC12309407 (available on 2026-05-01)
DOI: 10.1126/science.adt3527

Abstract

Expanded research opportunities in deceased humans require ongoing ethical inquiry.

MeSH terms

Biomedical Research* / ethics
Cadaver
Death*
Humans
Organ Preservation* / ethics
Tissue and Organ Procurement* / ethics
Tissue and Organ Procurement* / methods

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