Development and aging of resident endothelial stem cells in pre-existing blood vessels

Fitriana N Rahmawati; Nobuyuki Takakura

doi:10.1016/j.exphem.2025.104795

Development and aging of resident endothelial stem cells in pre-existing blood vessels

Exp Hematol. 2025 Apr 29:104795. doi: 10.1016/j.exphem.2025.104795. Online ahead of print.

Authors

Fitriana N Rahmawati¹, Nobuyuki Takakura²

Affiliations

¹ Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan. Electronic address: fitriananr@biken.osaka-u.ac.jp.
² Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan; Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, Suita, Osaka, Japan. Electronic address: ntakaku@biken.osaka-u.ac.jp.

PMID: 40311858
DOI: 10.1016/j.exphem.2025.104795

Abstract

Organ-specific somatic stem cells play an important role in supporting tissue turnover and facilitating regeneration on injury. Hematopoietic stem cells are one of the most established organ-specific somatic cells that have been frequently used for transplantation therapy. Recently, there has been a growing interest in other organ-specific somatic cells, including vascular endothelial stem cells (VESCs). We have previously reported on the use of CD157 and CD200 as markers to isolate VESCs from adult mouse organs, particularly the liver. In this review, we aimed to summarize, based on our previous research, how CD157⁺CD200⁺ VESCs in the liver develop from the fetal stage to postnatal life, what transcriptional regulatory mechanisms govern them, and how VESCs change with aging.

Publication types

Review