Not all dimers are equal

Elife. 2025 May 2:14:e106980. doi: 10.7554/eLife.106980.

Abstract

Disease-causing mutations in the signaling protein BMP4 impair its secretion, but only when it is made as a homodimer.

Keywords: BMP4; cell biology; cell signaling; developmental biology; human mutations; prodomain.

Publication types

  • Editorial

MeSH terms

  • Animals
  • Bone Morphogenetic Protein 4* / chemistry
  • Bone Morphogenetic Protein 4* / genetics
  • Bone Morphogenetic Protein 4* / metabolism
  • Humans
  • Mutation
  • Protein Multimerization*

Substances

  • Bone Morphogenetic Protein 4
  • BMP4 protein, human